Ratiometric mode with dyads: a breakthrough in dynamic trapping and quantification for redox regulation in living cells

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2015,（3）
• 页码范围: 434-435
• 页数: 2页
• 语种: 中文
• DOI: 10.1007/s11426-015-5350-9

摘要

Redox-based post-translational modification of protein thiols has become an attractive strategy in cellular homeostasis and cell signaling.Due to the reductive end of the redox buffer network,the vicinal dithiol-containing proteins (VDPs) maintains an appropriate oxidation-reduction state of proteins through the reversible transformation from vicinal dithiols to disulfide,which is responsible for a variety of diseases,such as cancer,diabetes and neuro-degeneration.