Eukaryotic cells use endocytosis to regulate the cellular signaling transduction by modulating the number of available receptors and their activity at the plasma membrane.In addition to the well-studied clathrin-dependent endocytic pathway, various clathrin-independent mechanisms have been identified.The canonical clathrin-dependent endocytic pathway is characterized by the involvement of clathrin and adaptor proteins.Among the diverse clathrin-independent pathways, the caveolae-mediated endocytosis is one of thebest characterized.