Nuclear-uptake nanodrug delivery system for drug-resistant cancer therapy

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2015,（3）
• 页码范围: 438
• 页数: 1页
• 语种: 中文
• DOI: 10.1007/s11426-015-5349-2

摘要

The development of multidrug resistance (MDR) has become an increasingly serious problem in cancer therapy,making the long-term survival of patients with MDR-associated cancers extremely challenging.The cell-membrane overexpression of P-glycoprotein (P-gp),which can actively efflux various anticancer drugs from the cell,is a major mechanism of MDR.Nuclear-uptake nanodrug delivery systems,which enable intranuclear release of anticancer drugs,are expected to address this challenge by bypassing P-gp.However,before entering the nucleus,the nanocarrier must pass through the cell membrane,necessitating the coordination between intracellular and intranuclear delivery.To accommodate this requirement,Professor Weihong Tan's group at Hunan University has succeeded in developing a size-photocontrollable nuclearuptake nanodrug system based on DNA hybridization and the near-infrared (NIR)-induced photothermal effect of the goldsilver nanorod (NR) [1].