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摘要:
Psoriasis is a potentially debilitating inflammatory dermatosis affecting 0.2%-4.8%of the population worldwide causing a significant occupational,personal or psychosocial morbidity to these patients for life.The basic aim of psoriasis therapy is to control the disease to maximum possible extent and improve the patient’s quality of life.Management of triggers for flareups,lifestyle modifications,and dietary supplements are often recommended.Intermittent or rotational therapy with frequent alterations in treatment options is usually needed to reduce toxicity of anti-psoriatic drugs in the absence of safer alternatives.Currently,several biological agents categorized as either T-cell targeted(e.g.,Alefacept,Efalizumab)or cytokine modulating(e.g.,Adalimumab,Infliximab,Etanercept)are available for treating severe psoriasis.However,their high cost is often precluding for most patients.The usefulness of systemic(methotrexate,cyclosporine,acitretin or several other therapeutic agents)or topical(tar,anthralin,corticosteroids or calcipotriol ointments,phototherapy with or without psoralens)therapies has been well established for the management of psoriasis.The literature is also replete with benefits of less used non-standard and unconventional treatment modalities(hydroxycarbamide,azathioprine,leflunomide,mycophenolate mofetil,isotretinoin,fumarates,topical calcineurin inhibitors,peroxisome proliferator-activated receptors agonists,statins,sulfasalazine,pentoxifylline,colchicine,grenz ray therapy,excimer laser,climatotherapy and balneophototherapy,peritoneal dialysis,tonsillectomy,ichthyotherapy,etc.).These can be used alternatively to treat psoriasis patients who have mild/minimal lesions,are intolerant to conventional drugs,have developed side effects or achieved recommended cumulative dose,where comorbidities pose unusual therapeutic challenges,or may be as intermittent,rotational or combination treatment alternatives.
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篇名 Psoriasis treatment:Unconventional and non-standard modalities in the era of biologics
来源期刊 世界皮肤病学杂志 学科 医学
关键词 Acetretin Azathioprine Balneophototherapy Calcineurin inhibitors CALCIPOTRIOL Calcium dobesilate Climatotherapy Colchicine Cyclosporine DAPSONE Excimer laser Fumarates Grenz ray therapy Hydroxycarbamide Ichthyotherapy ISOTRETINOIN Leflunamide Methotrexate MYCOPHENOLATE mofetil Pentoxifylline Peritoneal dialysis Phototherpy Plaque PSORIASIS Peroxisome proliferator-activated receptors agonists Statins SULFASALAZINE Tonsillectomy
年,卷(期) sjpfbxzz_2016,(1) 所属期刊栏目
研究方向 页码范围 17-51
页数 35页 分类号 R
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
Acetretin
Azathioprine
Balneophototherapy
Calcineurin
inhibitors
CALCIPOTRIOL
Calcium
dobesilate
Climatotherapy
Colchicine
Cyclosporine
DAPSONE
Excimer
laser
Fumarates
Grenz
ray
therapy
Hydroxycarbamide
Ichthyotherapy
ISOTRETINOIN
Leflunamide
Methotrexate
MYCOPHENOLATE
mofetil
Pentoxifylline
Peritoneal
dialysis
Phototherpy
Plaque
PSORIASIS
Peroxisome
proliferator-activated
receptors
agonists
Statins
SULFASALAZINE
Tonsillectomy
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界皮肤病学杂志
不定期
2218-6190
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
72
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0
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