Impact of RAS and BRAF mutations on carcinoembryonicantigen production and pattern of colorectal metastases

• 作者: May Cho, Chie Akiba, Cecilia Lau, David Smith, Milhan Telatar, Michelle Afkhami, Stephen Sentovich, Kurt Melstrom, Marwan Fakih
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: RAS BRAF Carcinoembryonic ANTIGEN PATTERN of METASTATIC disease SURVEILLANCE
• 年，卷（期）: 2016,（1）
• 页码范围: 128-135
• 页数: 8页
• 分类号: R

摘要

AIM To investigate the impact of RAS and BRAFmutations on the pattern of metastatic disease andcarcinoembryonic antigen （CEA） production.METHODS： In this retrospective study, we investigatedthe impact of RAS and BRAF mutational status on patternof metastatic disease and CEA production. Only patientspresenting with a newly diagnosed metastatic colorectalcancer （CRC） were included. Patients＇ characteristics,primary tumor location, site of metastatic disease andCEA at presentation were compared between those withand without RAS and BRAF mutations.RESULTS： Among 174 patients, mutations in KRAS ,NRAS and BRAF were detected in 47%, 3% and 6%respectively. RAS mutations （KRAS and NRAS ） weremore likely to be found in African American patients（87% vs 13%; P value = 0.0158）. RAS mutations wereassociated with a higher likelihood of a normal CEA （〈5 ng/mL） at presentation. BRAF mutations were morelikely to occur in females. We were not able to confirm any association between mutational status and site ofmetastatic disease at initial diagnosis.CONCLUSION： No association was found between RASand BRAF mutations and sites of metastatic disease atthe time of initial diagnosis in our cohort. Patients withRAS mutations were more likely to present with CEAlevels 〈 5 ng/mL. These findings may have clinical implicationson surveillance strategies for RAS mutant patientswith earlier stages of CRC.