HOXB13 and other high penetrant genes for prostate cancer

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2016,（4）
• 页码范围: 530-532
• 页数: 3页
• 语种: 中文
• DOI: 10.4103/1008-682X.175785

摘要

Camcer initiation and progression is the result of an accumulation of mutations in key tumor suppressor genes,mismatch repair genes,or oncogenes,which impact cancer cell growth,death,and differentiation.Mutations occurring in cancer tissue are termed somatic;whereas,heritable mutations that may be passed onto subsequent generations occur in germline DNA.It is these germline mutations that can lead to cancer family syndromes whereby family members carrying a deleterious germline mutation have an increased susceptibility to certain cancer phenotypes.Common features of hereditary cancer syndromes indude early age-of-onset,multiple affected generations,rare tumor types,and/or multiple primary malignancies.