Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（4）
• 页码范围: 389-390
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2016.43

摘要

Ubiquitin (Ub),a 76-residue polypeptide that is present in all eukaryotes,can be covalently conjugated to other proteins or other Ub molecules.Such ubiquitination (or ubiquitylation) reactions involve a cascade of reactions catalyzed by E1 (ubiquitin-activating enzyme),E2 (ubiquitin-conjugating enzyme) and E3 (ubiquitin ligase)proteins.The human Ub system encompasses ～40 E2s and ～700 E3s that specifically recognize and conjugate Ub to their substrates,including other Ub molecules.Protein ubiquitination is reversed by deubiquitinating enzymes (DUBs),which number close to 100in humans.