New frontiers of N-heterocyclic carbene catalysis

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2016,（3）
• 页码范围: 251-254
• 页数: 4页
• 语种: 中文
• DOI: 10.1007/s11426-015-5514-7

摘要

N-heterocyclic carbene (NHC) is both a family of strong σ-donor ligands for transition metals and a privileged class of organocatalysts with synthetic potential that rivals popular amine and phosphoric acid catalysts.NHC was found as a key catalytic species in thiamine diphosphate catalyzed biochemical reactions [1].However,due to their inherent chemical instability,free NHCs had not been isolated until 1991 by Ardungo et al.[2].Since then,the use of chiral NHC as a versatile organocatalyst has enjoyed tremendous advances and has helped to transform modern synthetic chemistry.There are over 2000 research papers dealing with both "N-heterocyclic carbene" and "Catalysis" in the past 15 years [3].