Gastric adenocarcinoma of fundic gland type： Endoscopicand clinicopathological features

• 作者: Gen Tohda Masaki Dochin Shintarou Terahata Takeshi Osawa Yasuyuki Asada
• 来源期刊: 世界胃肠内镜杂志：英文版（电子版）
• 学科: 医学
• 关键词: Early GASTRIC cancer Low grade MALIGNANCY Fundic GLAND TYPE CHIEF cells ENDOSCOPIC submucosaldissection
• 年，卷（期）: 2016,（4）
• 页码范围: 244-251
• 页数: 8页
• 分类号: R

摘要

Gastric adenocarcinoma of fundic gland type （GA-FG）with chief cell differentiation was recently proposed asan extremely rare type of gastric adenocarcinoma. Here,we report 4 cases of GA-FG with chief cell differentiation.Endoscopic features included a submucosal tumor shapeor a flat shape, whitish discolorationand dilated vesselson the surface. The tumors were located in the upper ormiddle third of the stomach. All cases were preoperativelydiagnosed as GA-FG by biopsy, and endoscopic submucosaldissection was performed. Resected specimensrevealed well-differentiated adenocarcinomas resemblingchief cells. Tumor cells were diffusely positive for pepsinogen-Ⅰ,but partially positive for H＋/K＋-ATPase inscattered locations around the tumor margin. Despitethe presence of minimal invasion of the carcinoma intothe submucosal layer, which was observed in two cases,neither lymphatic nor venous invasion was detected inany of the cases. Finally, all cases showed less aggressiveclinical behavior with low grade malignancy.