Drosha and Dicer: Slicers cut from the same cloth

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（5）
• 页码范围: 511-512
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2016.19

摘要

DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor,which is essential for microRNA biogenesis.A recent study by Kwon et al.in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8,thereby unveiling the topology and interactions between components of the Microprocessor and insights into its ‘ruler’-based cleavage activity and function.