Are genetic biomarkers the future of male fertility testing?
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摘要:
Men with infertility are subjected to numerous diagnostic tests in attempts to determine the nature of their condition.Initially,medical,surgical,and birth histories are elicited with investigations including semen analyses,hormonal panels,and imaging studies such as scrotal or trans-rectal ultrasounds.In cases of men with nonobstructive azoospermia (NOA),these inquiries may all return normal results.More specific testing involving karyotyping and Y-chromosome microdeletion analysis are then performed.When all of these results are normal,a definitive diagnosis must be pursued in the form of a testicular biopsy to determine the physiological ability of the testicle to conduct spermatogenesis.