Suppression of enhancer overactivation by RACK7 and KDM5C

• 来源期刊: 中国科学基金（英文版）
• 年，卷（期）: 2016,（3）
• 页码范围: 14
• 页数: 1页
• 语种: 英文

摘要

Enhancers are important regulatory elements in controlling gene expression,and their activities are properly regulated to ensure normal development and differentiation.Recent cancer genome sequencing projects have identified frequent mutations of enhancer regulators,indicating dysregulation of enhancers may lead to detrimental consequences.New findings from the group led by Dr.Lan Fei (蓝斐) and Dr.Shi Yang from Fudan University revealed a previously underappreciated "overactivation state" of enhancers and a regulatory chromatin complex that suppresses the state.This study was recently published in Cell (April 7,2016,165:331-342).