Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2016,（3）
• 页码范围: 282-285
• 页数: 4页
• 语种: 中文
• DOI: 10.1093/jmcb/mjw018

摘要

Dear Editor, Prohibitin 1 (PHB1) was identified previously as a protein that is upregulated and translocated to the plasma membrane in taxane-resistant cancer ceils.We found that PHB1 silencing re-sensitized taxaneresistant cancer cells to apoptosis and to paclitaxel treatment both in vitro and in vivo (Patel et al.,2010).In line with our findings,overexpression of PHB1 has been shown to markedly attenuate ceramide-,staurosporine (STS)-,camptothecin-,or serum withdrawal-induced apoptosis via the intrinsic apoptotic pathway (Peng et al.,2015).