How I treat my inflammatory bowel disease-patients with thiopurines?

• 作者: Adriaan A van Bodegraven Berrie Meijer Chris JJ Mulder Nanne KH de Boer
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: THIOPURINES AZATHIOPRINE MERCAPTOPURINE THIOGUANINE 煽动性的肠疾病 监视的治疗学的药 怀孕 代谢物
• 年，卷（期）: 2016,（4）
• 页码范围: 524-530
• 页数: 7页
• 分类号: R574.62

摘要

Thiopurines are essential drugs to maintain remission in patients with inflammatory bowel disease(IBD).Thiopurines used in IBD are azathioprine(2.0-2.5 mg/kg),mercaptopurine(1.0-1.5 mg/kg) and thioguanine(0.2-0.3 mg/kg).However,mainly due to numerous adverse events associated with thiopurine use,almost 50% of the patients have to discontinue conventional thiopurine treatment.Extensive monitoring and the application of several treatment strategies,such as split-dose administration,co-administration with allopurinol or dose reduction/increase,may increase the chance of successful therapy.With this review,we provide practical information on how thiopurines are initiated and maintained in two thiopurine research centers in The Netherlands.We provide clinical information concerning safety issues,indications and management of therapy that may serve as a guide for the administration of thiopurines in IBD patients in daily practice.