With the support by the National Natural Science Foundation of China,the research team led by Prof.Zhang Wenbin (张文彬) at the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education,Center for Soft Matter Science and Engineering,College of Chemistry and Molecular Engineering,Peking University,reported a strategy to synthesize protein catenanes via direct expression in E.coli.The work was published in Angew Chem Int Ed (2016,55:3442-3446).