Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（1）
• 页码范围: 135-138
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2015.151

摘要

Dear Editor, Normal mammalian development requires participation of both maternal and paternal genomes because of the existence of genomic imprinting, whereas the gynogenetic and androgenetic embryos die shortly after implantation [1-3].Generation of gynogenetic bimaternal mice containing two sets of maternal genomes was achieved using non-growing oocytes with imprinting modifications [4];however, the approach was technically challenging and impractical for further applications.