Two paths for stabilization of ERG in prostate carcinogenesis: TMPRSS2-ERG fusions and speckle-type pox virus and zinc finger protein mutations

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2016,（4）
• 页码范围: 594-595
• 页数: 2页
• 语种: 中文
• DOI: 10.4103/1008-682X.168793

摘要

Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that specifically promotes the nbiquitination and proteasome degradation of proteins.SPOP mutations are frequent in prostate cancer,and in a previous study,An et al.demonstrated that SPOP induced the degradation of the androgen receptor (AR) suggesting that SPOP is important in maintaining prostate homeostasis.In this current highlighted report,An and colleagues showed that ERG,which has been implicated as an oncoprotein in prostate cancer,contains putative SPOP-binding consensus (SBC) motifs 42ASSSS46 and 423VTSSS427 in the N-and C-terminal of ERG,respectively.