With the support by the National Natural Science Foundation of China and 973 Program,Lin et al.from the State Key Laboratory of Silkworm Genome Biology,Southwest University,reported the impact and mechanism of Bacillus bombysepticus (Bb) α-toxin in GRK2-mediated GPCR desensitization that regulates cAMP/PKA signaling to induce host death.Their work has been published in Plos Pathogens (2016,12(3):e1005527).