Warm feelings for TRPM2

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（11）
• 页码范围: 1174-1175
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2016.121

摘要

Two recent studies reveal a crucial role for the cation channel TRPM2 in sensing warm temperatures,both in the thermoregulatory center of the brain and in the somatosensory system. Temperature directly impacts the function of biological macromolecules and every (bio)chemical reaction.To ensure that the body functions at a metabolically favorable temperature,mammals and other endotherms exhibit powerful thermoregulatory processes that maintain the body core temperature (Lore) within a narrow temperature band [1].In healthy humans,Lore is typically maintained between 36.5 and 37.5 ℃.Deviations from normothermia of only a few degrees,for instance due to disease,drug abuse or extreme environmental conditions,can have dangerous and even fatal consequences;temperatures ＞ 40 ℃ or ＜ 32 ℃ represent an acute medical urgency.