Monocyte-derived Wnt5a regulates inflammatory lymphangiogenesis

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（2）
• 页码范围: 262-265
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2015.105

摘要

Dear Editor, Lymphatic research signifies a field of explosive discovery in recent years [1-3].The lymphatic network penetrates most tissues in the body and its dysfunction has been found in a broad spectrum of disorders from inflammation to cancer metastasis and transplant rejection.However,to date,there are few effective treatments for lymphatic diseases.It is therefore important and urgent to investigate the fundamental mechanisms of pathological lymphangiogenesis (LG,the formation of new lymphatic vessels) for the development of new therapeutic strategies.The cornea offers an ideal site for pathological LG research due to its transparent nature and inducible LG [3].Since there are no pre-existing or background vessels to consider,it is exceptionally straightforward and accurate to assess LG in response to a pathological insult,such as inflammation.