The genome-wide mutational landscape of pituitary adenomas

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（11）
• 页码范围: 1255-1259
• 页数: 5页
• 语种: 中文
• DOI: 10.1038/cr.2016.114

摘要

Dear Editor, Pituitary adenomas (PAs) are one of the most common intracranial tumors,which can result in significant morbidity and can cause mortality either by exerting central pressure effects from the pituitary mass or by secreting excessive pituitary hormones [1].Depending on their capability to produce hormones,PAs are classified as clinically functioning and nonfunctioning (NF).Functioning PAs include 6 subtypes,characterized by hypersecretion of prolactin (PRL),growth hormone (GH),adrenocorticotropin (ACTH),gonadotropins including follicle stimulating hormone and luteinizing hormone (GT),thyrotropin (TSH) or multiple hormones (plurihormonal),respectively.We and other group recently reported the recurrent genetic mutations in ACTH-PAs [2,3].Previous studies also identified genetic alterations in GH-PAs by wholegenome and-exome sequencing [4,5] and in 7 NF-PAs by exome analysis [6].Due to challenges in collection and preparation of PA samples,exome-wide sequencing of other subtypes,including the PRL-,GT-,TSH-,and plurihormonal PA subtypes,has not been reported yet.