YEATS2 is a selective histone crotonylation reader

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（5）
• 页码范围: 629-632
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2016.49

摘要

Dear Editor, Histone lysine crotonylation (Kcr) is a recently identified non-acetyl acylation conserved from yeast to human.We have previously shown that histone Kcr marked active chromatin and was enriched at promoter and enhancer regions [1].Different from the histone lysine acetylation (Kac),histone Kcr preferentially marks "escapee genes" during post-meiotic gene inactivation,suggesting a unique regulatory mechanism centered on Kcr independent of Kac [2].Nevertheless,in contrast to the histone Kac readers that are well documented,selective readers for histone Kcr remain unknown.Although a few bromodomain-containing proteins (e.g.,TAF1) were shown to recognize Kcr,their binding affinities are much compromised as compared to Kac binding [3].