Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex

• 来源期刊: 中国科学基金（英文版）
• 年，卷（期）: 2016,（4）
• 页码范围: 54
• 页数: 1页
• 语种: 英文

摘要

With the support by the National Natural Science Foundation of China,the research team led by Prof.Yu Yongchun (禹永春) at the Institutes of Brain Science,Fudan University,revealed the vital roles of electrical coupling in chemical synapse formation between interneurons,which was published in Nature Communications (2016,7:12229,DOI:10.1038). Although the excitatory neurons in the neocortex are electrically coupled only during early development,it is well established that interneurons maintain their functional gap junctions into adulthood in the neocortex.It has long been postulated that the formation of electrically coupled neuronal domains might help to guide the emergence of chemically transmitting neuronal circuits in the developing neocortex.However,whether electrical coupling can modulate chemical synapse formation between interneurons has rarely been reported.