4-67 miR-300 Modulates the Cellular Radiosensitivity Through Targeting p^53 in Human Non-small Cell Lung Cancer A549 Cells

• 作者: Ding Nan Feng Xiu He Jinpeng Hua Junrui Jin Liangliang Li He Lu Zhiwei Wang Jufang Wei Wenjun Zhang Yanan
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 年，卷（期）: 2016,（1）
• 页码范围: 193-194
• 页数: 2页
• 分类号: O4

摘要

microRNAs(miRNAs)perform crucial roles in mediation of the cellular radiosensitivity by influencing DNA damage repair,cell cycle checkpoint,apoptosis,radio-related signal transduction pathway and microenvironment[1-3].Our previous study have suggested that miR??300,whose expression is correlated positively with the cellular resistance to chemotherapy drug cis-platin in human ovarian cancer cells[4],is involved in the cellular response to the DNA damages induced by ionizing radiation[5].However,the underlying molecular mechanisms remain unclear.