Stem cells are undifferentiated cells that retain the ability to self-renew and differentiate into specialized cells,offering a promising resource to generate requisite cell types in regenerative medicine [1,2].Haematopoietic stem cells (HSCs) can differentiate into entire mature blood lineages,sitting at the apex of the haematopoietic hierachy and playing a key role in the long-term maintenance and stabilization of mammalian blood system functions [3,4].