Lipid metabolism and diseases

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2016,（19）
• 页码范围: 1471-1472
• 页数: 2页
• 语种: 中文
• DOI: 10.1007/s11434-016-1174-z

摘要

Lipids are a large and diverse class of biomolecules that exert multiple biochemical functions,such as fueling energy production,and building blocks for plasma membrane and chemical signals during cellular communication.Lipids have been found especially important in such tissues as the adipose tissue,liver and intestine for energy storage or lipid turnover [1],while accreted in the skeletal muscle,mammary glands,macrophages and adrenal cortex [2].Under energy-rich conditions,lipids synthesis is highly conservative;under energy-poor conditions,lipids accumulation enables organisms to survive,and stored lipids are then utilized in need of energy production.As evidenced,abnormal lipid metabolism is associated with type 2 diabetes mellitus,obstructive sleep apnea,coronary artery disease,nonalcoholic fatty liver diseases,cancer,etc.[3,4].Much research has been conducted to reveal the essential roles of lipid metabolism in energy homeostasis and metabolic diseases.The discovery of diverse characteristics of lipids may shed light on new therapeutic strategies for metabolic diseases.