PI4Kβ, PIPs and BKCa channel function

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2016,（23）
• 页码范围: 1779-1782
• 页数: 4页
• 语种: 中文
• DOI: 10.1007/s11434-016-1186-8

摘要

Large conductance calcium-activated potassium (BKCa) channels are broadly expressed in vascular smooth muscle cells (VSMCs) and play a crucial role in the regulation of vascular tone [1].Activation of BKCa channel by elevation of the [Ca2+]i due to membrane depolarization increases the K+ conductance of the membrane,and drives the VSMC membrane potential to hyperpolarization,which in turn,closes the L-type voltage-dependent Ca2+ channels,decreases the global [Ca2+]i of VSMCs,and induces vascular relaxation [2].Enhancing the BKCa current is a practicable strategy in treating diseases with increased vascular tone such as hypertension and coronary artery syndrome [2-4].