The new face of iron oxide nanoparticles: the bullets targeting tumor microenvironment for cancer therapy
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摘要:
Ferumoxytol,an iron replacement product in clinic practices,is an agent of superparamagnetic iron oxide nanoparticles coated with polyglucose sorbitol carboxymethylether.It is approved for the intravenous therapy of iron deficiency anemia in patients with chronic kidney disease.Compared with oral iron therapy which is poorly tolerated in many patients with gastrointestinal disorders,ferumoxytol has been considered as an efficacious and well-tolerated option for these patients [1].Besides of the iron supplement agent,ferumoxytol is also used for diagnosis owing to its magnetic resonance imaging (MRI)-based diagnostic capability.Many reports have shown that iron oxide nanoparticle-labeled cells can be tracked in the tissue and body [2].