Photoredox-catalyzed amide-directed selective sp3 C-H bond functionalization

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2016,（24）
• 页码范围: 1892-1893
• 页数: 2页
• 语种: 中文
• DOI: 10.1007/s11434-016-1212-x

摘要

Over the past century,transition metal-catalyzed crosscoupling reactions have evolved to be among the most used C-C bond forming reactions in chemical synthesis.An important remaining challenge is to synthesis with heightened levels of efficiency by new method.A powerful new class of reactions that introduce oxidized functionality directly into sp3 C-H bonds of hydrocarbons is emerging [1,2].Despite important advances in the aliphatic C-H bond activations,selective functionalization with complex substrates has only been demonstrated for activated C-H bonds such as location adjacent to a heteroatom or substrate with directing groups [3].High-efficient oxidations of isolated,unactivated sp3 C-H bonds are rare.The challenge to solve this problem lies in discovering new methodology that is both highly efficient and predictably selective for oxidizing these inert C-H bonds.