Smoking and the risk of dry eye： a Meta-analysis

• 作者: Li Xu Tao Suo Wei Zhang Xian-Qun Fan Xiao-Yu Zhu Yao Fu
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 年，卷（期）: gjykzzywb_2016,（10）
• 页码范围: 1480-1486
• 页数: 7页
• 分类号: R77

摘要

AIM: To collect the evidence to estimate the correlation between smoking and the incidence of dry eye. METHODS: The Pub Med,EMBASE,the Cochrane Central Register of Controlled Trials(CENTRAL,last issue),CBM(Chinese Bio Medical Literature Database),and CNKI(China National Knowledge Infrastructure/Chinese Academic Journals full-text Database) were searched for eligible studies published from January1964 to December 2015 to investigate the association of smoking with the risk of dry eye.The odds ratio(OR)and 95% confidence interval(CI) were summarized and calculated.The extracted studies were pooled by the fixed-effects model or a random-effects model. RESULTS: Two cohort studies and eight cross-sectional surveys were included in our Meta-analysis.There was no statistically significant relationship between current(OR=1.32; 95% CI: 0.99-1.76; P=0.055)or ever smoking(OR=1.12; 95% CI: 0.98-1.28; P=0.107)and the risk of dry eye among the studies,even when age and gender were adjusted(OR=1.16; 95% CI: 0.83-1.64; P=0.383).In the sensitivity analysis in which only general population were included,the association was significant between smoking and dry eye(OR=1.50; 95%CI: 1.08-2.09; P=0.016).CONCLUSION: This Meta-analysis suggests that smoking may associate with the risk of dry eye in general population.