In recent years some studies show that probiotics can regulate the body's immune response and in addition to study most of Lactobacillus and Bifidobacterium,Clostridium butyricum also has its unique immune regulatory role.These probiotics are expected to be used in the treatment of allergic diseases,but its mechanism of action is not clear,and the current of probiotics on allergic disease mechanisms research conclusion still exist some contradictions,besides whether the clinical symptoms of the allergic disease can be improve is unclear,so the probiotics have not been recommended to routine treatment of allergic diseases.This review will help us further understand the probiotics on allergic disease mechanism and the unique role of Clostridium butyricum.