Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

• 作者: Keitaro Hayashi Naohiko Anzai
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: LAT1 氨基酸 transporter 分子的目标药 氨基酸饥饿反应 信号 transduction
• 年，卷（期）: 2017,（1）
• 页码范围: 21-29
• 页数: 9页
• 分类号: R730.5

摘要

L-type amino acid transporters(LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs(LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1(SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review.