Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: MIM-B human lung giant-cell carcinoma cell invasion DNMT1
• 年，卷（期）: 2017,（3）
• 页码范围: 238-245
• 页数: 8页
• 语种: 英文
• DOI: 10.1093/abbs/gmw138

摘要

Missing in metastasis B (MIM-B) has been widely reported to inhibit cancer cell invasion and proliferation in a variety of human cancers.However,the functions of MIM-B in lung cancers are still controversial.In addition,the mechanisms and regulation of MIM-B are poorly understood.In the present study,we found that the invasion level of 95C human lung giant-cell carcinoma cells was elevated when MIM-B was knocked down,while the invasion of 95D was suppressed when MIM-B was overexpressed,proving that MIM-B suppresses human lung giant-cell carcinoma cell invasion,which is similar to its function in most cancers.Furthermore,we reported that an increase in DNA methylation density in the promoter of MIM-B by DNA methyltransferase 1 (DNMT1) is correlated with the silencing of MIM-B expression and the high metastasis of 95D human lung giant-cell carcinoma cell line.Taken together,MIM-B,which is regulated by DNMT1 through DNA methylation,is a putative cancer suppressor in human lung giant-cell carcinoma.