New discoveries generate new questions about RNA-directed DNA methylation in Arabidopsis

• 来源期刊: 国家科学评论（英文版）
• 关键词: DNA methylation
• 年，卷（期）: 2017,（1）
• 页码范围: 10-15
• 页数: 6页
• 语种: 英文
• DOI: 10.1093/nsr/nwx008

摘要

Plants can establish de novo DNA methylation via the RNA-directed DNA methylation (RdDM) pathway,which involves a complex array of proteins as well as small interfering RNAs (siRNAs) and scaffold RNAs.In the canonical RdDM pathway that is best under-stood in Arabidopsis,complementary pairing between 24-nt siRNAs and nascent scaffold RNAs,together with protein-protein interactions,recruits the protein machinery for DNA methylation.