Rheumatic Mineralization of Aortic Valve and Anterior Mitral Leaflet—A Case Report

• 作者: Ramachandran Muthiah
• 来源期刊: 临床医学病理报告(英文)
• 学科: 医学
• 关键词: RHEUMATIC MINERALIZATION Mitral-Aortic “J-Shaped” Calcification “Mushroom Shaped” Calcified Bicuspid AORTIC Valve Hutchinson-Gilford PROGERIA Syndrome Therapeutic Strategies
• 年，卷（期）: 2017,（4）
• 页码范围: 95-119
• 页数: 25页
• 分类号: R5

摘要

Aim: To present the heterotopic ossification of left-sided heart valves due to rheumatic inflammation and biomineralization. Introduction: Calcification in the region of mitral-aortic continuity is significant at its origin and etiopathogenesis. The etiology of valvular calcification may be divided into 3 groups, namely, inflammation, degeneration and metabolic disturbances. Calcification of cardiac valve leaflets is most often due to rheumatic etiology in tropical nations. Case Report: A 52-year-old male developed sudden onset of light-headedness and palpitations due to atrial fibrillation. Transthoracic 2D echocardiography revealed calcification of anterior mitral leaflet and aortic valve which resembles a bone-like structure and the patient was advised double valve replacement. Conclusion: It was known that the cellular mechanisms play an important role in its genesis and therapeutic strategies are targeted to reverse this process by understanding its biological mediators.