Qualitative Analysis of A Sulfur-fumigated Chinese Herbal Medicine by Comprehensive Two-Dimensional Gas Chromatography and High-Resolution Time of Flight Mass Spectrometry Using Colorized Fuzzy Difference Data Processing

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2017,（4）
• 页码范围: 261-269
• 页数: 9页
• 语种: 英文
• DOI: 10.1007/s11655-015-1966-z

摘要

Objective:To investigate the chemical transformation of volatile compounds in sulfur-fumigated Radix Angelicae Sinensis.Methods:A comprehensive two-dimensional gas chromatography (GC × GC) and high-resolution time-of-flight mass spectrometry (HR-TOF/MS) with colorized fuzzy difference (CFD) method was used to investigate the effect of sulfur-fumigation on the volatile components from Radix Angelicae Sinensis.Results:Twenty-five compounds that were found in sun-dried samples disappeared in sulfur-fumigated samples.Seventeen volatile components including two sulfur-containing compounds were newly generated for the first time in volatile oils of sulfur-fumigated Radix Angelicae Sinensis.Conclusion:The strategy can be successfully applied to rapidly and holistically discriminate sun-dried and sulfur-fumigated Radix Angelicae Sinensis,GC × GC-HR-TOF/MS based CFD is a powerful and feasible approach for the global quality evaluation of Radix Angelicae Sinensis as well as other herbal medicines.