Anaphylactic Shock Due to Allergy to Macrogol 4000 Contained in SonoVue<sup>&reg</sup>

• 作者: Arturo Velasco Arregui Italo Girao Popolizio Nagore Arruti Oyarzabal Nagore Bernedo Belar Natividad Longo Areso Olga Villarreal Balza de Vallejo
• 来源期刊: 临床医学病理报告(英文)
• 学科: 医学
• 关键词: SonoVue® Macrogol Polyethylene GLYCOL (PEG) TWEEN 80 Ultrasound Contrast Agents ALLERGY
• 年，卷（期）: 2017,（6）
• 页码范围: 143-147
• 页数: 5页
• 分类号: R73

摘要

SonoVue&reg (Bracco;Milan, Italy) is an ultrasound contrast medium which contains polyethylene glycol (PEG) or macrogol, an excipient responsible for severe allergic reactions, especially through the parenteral route, and widely used, especially in the health field. We present an adult patient who experienced an IgE-mediated anaphylactic shock due to macrogol contained in SonoVue&reg, as demonstrates the skin tests realized. The allergy study has been useful in our case because it has guided us in the preventive measures to advice to the patient, who has to avoid not only SonoVue&reg but also other products that contain macrogol. We consider this case of interest because it is an allergic adverse reaction to SonoVue&reg in which its excipient, macrogol, has acted like the allergen responsible. We have to add SonoVue&reg to the list of the products that contain macrogol in their composition and keep in mind the possible allergenic capacity of this excipient for suspecting its responsibility, especially in those patients with multiple drug allergy and/or reactions to products of different natures like ultrasound gels, topical products (e.g. toothpastes, antiseptics, sunscreens, etc.), plasma expanders and others.