α-Asarone suppresses the proliferation and migration of ASMCs through targeting the lncRNA-PVT1/miR-203a/E2F3 signal pathway in RSV-infected rats

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: RSV-induced asthma airway smooth muscle cell lncRNA-PVT1 miR-203a E2F3
• 年，卷（期）: 2017,（7）
• 页码范围: 598-608
• 页数: 11页
• 语种: 英文
• DOI: 10.1093/abbs/gmx048

摘要

Asthma is a chronic inflammatory pulmonary disease and respiratory syncytial virus (RSV) infection is a common cause of lower respiratory tract illness in infants and young children.α-Asarone presents many pharmacological effects and has been demonstrated to be useful in treating asthma.However,the functional mechanism of α-asarone in RSV-infected asthma has not been investigated.Long non-coding RNAs (lncRNAs) have been reported to play critical roles in many biological processes.Although many lncRNAs have been characterized,few were reported in asthma,especially in RSV-induced asthma.Currently,a novel post-transcriptional regulation has been proposed in which lncRNAs function as competing endogenous RNAs (ceRNAs) to competitively sponge miRNAs,thereby regulating the target genes.In the present study,we established an RSV-infected Sprague-Dawley rat model and demonstrated that lncRNA-PVT1 is involved in the mechanism of α-asarone in treating RSV-induced asthma,and lncRNA-PVT1 regulates the expression of E2F3 by functioning as a ceRNA which competitively sponges miR-203a.