Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2017,（3）
• 页码范围: 307-311
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s12264-016-0079-9

摘要

Patients with schizophrenia undergo changes in brain plasticity.In the present study,we characterized motor cortical-striatal plasticity in such patients.Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group,the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles.Notably,the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task.Moreover,the loss of plasticity was correlated with the symptoms of schizophrenia.The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning.