Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base

• 作者: L. K. Ravindranath Ramakrishna Vellalacheruvu Ramayanam Sai Leela
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: IMIDAZOLE ANALOGUES Thiozolidine-2 4-Dione NUCLEUS Toluenesulfonylmethyl ISOCYANIDE Combi-Flash Column Chromatography
• 年，卷（期）: 2017,（3）
• 页码范围: 269-283
• 页数: 15页
• 分类号: O6

摘要

The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivatives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.