The modification of natural products for medical use

• 来源期刊: 药学学报（英文版）
• 关键词: Natural products Synthesis Multi-dimensional optimization Structure-acitivity reactivity Artemisinin Indirubin
• 年，卷（期）: 2017,（2）
• 页码范围: 119-136
• 页数: 18页
• 语种: 英文

摘要

Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development.Similarly,natural products are chemically tailored and modified based upon their structural and biological properties.To some extent,the modification of natural products is quite different from de novo structure-based drug discovery.This review describes the general strategies and principles for the modification of natural products to drugs,as illustrated by several successful medicines that originated from natural products.