The transmission of infectious diseases is a dynamic process determined by multiple factors originating from disease pathogens and/or parasites,vector species,and human populations.These factors interact with each other and demonstrate the intrinsic mechanisms of the disease transmission temporally,spatially,and socially.In this article,we provide a comprehensive perspective,named as systems thinking,for investigating disease dynamics and associated impact factors,by means of emphasizing the entirety of a system's components and the complexity of their interrelated behaviors.We further develop the general steps for performing systems approach to tackling infectious diseases in the real-world settings,so as to expand our abilities to understand,predict,and mitigate infectious diseases.