Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study

• 作者: Albert P Aldenkamp Anton J A de Louw Dominique M IJff Jacobus F A Jansen Paul A M Hofman Richard H C Lazeron Tamar M van Veenendaal Walter H Backes
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: 镇癫痫剂药 认知副作用 大脑网络 休息状态 功能的磁性的回声成像 图分析
• 年，卷（期）: 2017,（6）
• 页码范围: 287-294
• 页数: 8页
• 分类号: R445.2

摘要

AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects.