Aromatic compounds from an aqueous extract of "ban lan gen" and their antiviral activities

• 来源期刊: 药学学报（英文版）
• 关键词: Cruciferae Isatis indigotica Aromatic metabolite Antiviral activity
• 年，卷（期）: 2017,（2）
• 页码范围: 179-184
• 页数: 6页
• 语种: 英文

摘要

A pair of new diphenyl glycerol ether enantiomers (-)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3,named (-)-(R)-and (+)-(S)-isatindigotrioic acid [(-)-1 and (+)-1] and isatindigoticamides A (2) and B (3),respectively,were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen).Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments.The absolute configurations of (-)-1 and (+)-1 were assigned based on the CD exciton chirality method.Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC50 values of 4.87 and 25.87 μmol/L,respectively.Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production.