deSUMOylation signaling: a novel mechanism of liver CSC properties and hepatocarcinogenesis in hypoxia

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: @@
• 年，卷（期）: 2017,（12）
• 页码范围: 1135-1137
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmx109

摘要

Hepatocellular carcinoma (HCC),one of the most common malignant cancers,is the third leading cause of cancer-related mortality worldwide.The etiological factors of HCC include alcohol intake,smoking,viral infections,cirrhosis,non-alcoholic steatohepatitis,hemochromatosis,and diabetes.Nowadays,despite much advance in HCC treatment,the 5-year survival rate for patients keeps dismal due to recurrence and metastases of HCC.Cancer stem cells (CSCs),also termed tumor-initiating cells,have the capability for unrestricted cell division,contributing to heterogeneous cell progenies.CSCs exist in both solid tumors and hematological malignancy.Till now,some cell surface markers are widely used to identify a subpopulation of cells with CSC features in liver such as CD24,CD133,and epithelial cell adhesion molecule.Therefore,identification of CSC subpopulations in tumor will provide a novel understanding for cancer progress.