Prevalence of Kaposi's sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China

• 来源期刊: 中国病毒学
• 年，卷（期）: 2017,（5）
• 页码范围: 396-403
• 页数: 8页
• 语种: 英文
• DOI: 10.1007/s12250-017-4049-9

摘要

Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma (KS),primary effusion lymphoma,and multicentric Castleman disease.It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDS-associated KS are found mostly among people of Uygur ethnicity in Xiniiang,while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China.However,it is still unclear why there is such geographical and population variation in KSHV distribution in China.In this work,we focused on the populations in the Kashgar region and Urumqi area,where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjlang,and to determine risk factors that may affect KSHV infection rates or KS incidence.We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang,and determined that advancing age,low education level,and stationary population status affect KSHV infection rates.Further,KSHV-positivs Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.