Prevalence of Kaposi's sarcoma-associated herpesvirus among intravenous drug users: a systematic review and meta-analysis

• 来源期刊: 中国病毒学
• 年，卷（期）: 2017,（5）
• 页码范围: 415-422
• 页数: 8页
• 语种: 英文
• DOI: 10.1007/s12250-017-4051-2

摘要

Intravenous drug users (IDUs) have been demonstrated to be highly vulnerable to HIV/AIDS.Nevertheless,the prevalence of Kaposi's sarcoma associated herpesvirus (KSHV),an important co-infected agent with HIV,among this population remained obscure.We conducted a systematic review on the epidemiological features of KSHV among IDUs worldwide.Eligible studies were retrieved from 6 electronic databases (PubMed,EMBASE,Web of Science,CBM,CNKI and Wanfang).We calculated the pooled prevalence and 95％ confidence interval (Cl) overall and among subgroups using either random-effects model or fixed-effects model depending on between-study heterogeneity.The potential publication bias was assessed by the Egger's test.A meta-regression analysis was performed to explore the sources of heterogeneity.Finally,twenty-two studies with a total sample of 7881 IDUs were included in the analysis.The pooled prevalence of KSHV was 14.71％ (95％ Cl 11.12％-19.46％) among IDUs.Specifically,KSHV prevalence was 10.86％ (95％ Cl 6.95％-16.96％) in HIV-negative IDUs,and 13.56％ (95％ Cl 10.57％-17.38％) in HIV-positive IDUs.Moreover,prevalence among IDUs from the three continents involved in the current study was similar:16.10％ (95％Cl 7.73％-33.54％) in Asia;14.22％ (95％Cl 8.96％-22.57％) in Europe and 14.06％ (95％Cl11.38％-17.37％) in America.Globally,IDUs are at higher risk of the KSHV infection when compared with the general population,regardless of geographical region or HIV-infection status.