Recent progress on chikungunya virus research

• 来源期刊: 中国病毒学
• 年，卷（期）: 2017,（6）
• 页码范围: 441-453
• 页数: 13页
• 语种: 英文
• DOI: 10.1007/s12250-017-4072-x

摘要

Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitos in tropical and subtropical regions across the world.After decades of sporadic outbreaks,it re-emerged in Africa,Asia,India Ocean and America suddenly,causing major regional epidemics recently and becoming a notable global health problem.Infection by CHIKV results in a spectrum of clinical diseases including an acute self-limiting febrile illness in most individuals,a chronic phase of recurrent join pain in a proportion of patients,and long-term arthralgia for months to years for the unfortunate few.No specific anti-viral drugs or licensed vaccines for CHIKV are available so far.A better understanding of virus-host interactions is essential for the development of therapeutics and vaccines.To this end,we reviewed the existing knowledge on CHIKV's epidemiology,clinical presentation,molecular virology,diagnostic approaches,host immune response,vaccine development,and available animal models.Such a comprehensive overview,we believe,will shed lights on the promises and challenges in CHIKV vaccine development.