Megastigmane glucosides isolated from Dichrocephala benthamii

• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2017,（4）
• 页码范围: 288-291
• 页数: 4页
• 分类号: R284
• 语种: 英文
• DOI: 10.3724/SP.J.1009.2017.00288

摘要

The present study was designed to investigate the chemical constituents of the whole herb ofDichrocephala benthamii.A aew megastigmane glucoside (compound 1),together with its four known analogues (compounds 2-5),was obtained.Their structures were elucidated on the basis of spectroscopic analyses (UV,IR,MS,and 1D and 2D NMR).The absolute configuration of compound 1 was assigned on the basis of CD method and chemical evidence.In addition,their cytotoxicity against human hepatoma cells (HepG-2) was evaluated by the MTT method.Compound 5 showed weak activity against HepG-2,while the other compounds did not show remarkable inhibitory effects.