Highly regioselective hydroformylation of olefins with formic acid instead of toxic and flammable CO/H2

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2017,（7）
• 页码范围: 839-840
• 页数: 2页
• 语种: 英文
• DOI: 10.1007/s11426-016-9004-4

摘要

Hydroformylation is an atom-economic and highly efficient transformation from readily available olefins to various synthetically important carbonyl compounds [1].By using this transformation,the largest amount of fine chemicals have been produced in the global chemical industry every year.However,the toxicity and flammability of the syngas (CO/H2)have hampered application of the conventional hydroformylation into organic synthesis in laboratories and pharmaceutical industry.Therefore,development of new processes using CO/H2 surrogates may further release the synthetic potentiality of hydroformylation.Much effort has been contributed to the research topic,such as hydroformylation of olefins with formaldehyde and alcohols as the syngas surrogates.Besides the hazard and inconvenience of syngas,regioselectivity is also a widely concemed issue for olefin hydroformylation.High regioselctivity for linear aldehyde or for branched aldehyde is highly desirable from the synthetic point of view.